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Special cargo in air transport refers to goods requiring exceptional handling due to their nature (e.g., dangerous goods, perishables), value, size, or weight. Compliance with IATA Dangerous Goods Regulations (DGR) and airline-specific rules is mandatory. This guide covers key categories (lithium batteries, live animals, pharmaceuticals), documentation (MSDS, UN certification), and operational protocols (packaging, priority loading). Always consult airlines or IATA CEIV-certified agents 72+ hours before shipment.